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On physical examination, neuropathy, abdominal distention, succussion splash, foul breath and orthostatic and postprandial hypotension may be present, but these findings are nonspecific for gastroparesis [71]

21 Polymorphisms in HNMT (like the Thr105Ile variant) can result in 30-50% lower enzyme activity

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Wegovy does not require biliary excretion for its metabolismit is broken down by proteolytic enzymes throughout the body, as detailed in the European Medicines Agency's European Public Assessment Report (EPAR)